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Peripheral artery disease (PAD) is a circulatory problem that limits blood flow to the extremities

The margin between proper storage and complete product failure is narrower than most protocols acknowledge

Twice subacute MPTP administrations induced time-dependent dopaminergic neurodegeneration and inflammation in midbrain and ileum, as well as gut microbiota disorders in PD mice

Most therapeutic peptides are rapidly cleaved by gastric acid and luminal proteases (pepsin, trypsin, chymotrypsin) before meaningful absorption can occur

Nat Rev Drug Discov (2011) 10:37793.10.1038/nrd3430 90 ChaudhuriKRSchapiraAH

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