Caspase-8, for instance, is able to directly cleave pro-IL-1, thus activating (and not inhibiting), through signal transduction, the necroptotic pathway, which is known to culminate in cell lysis accompanied with inflammation [128]
and a high proportion of their omega-6 fatty acids in the form of long-chain omega-6 arachidonic acid (AA)
Furthermore, pathological -syn spreads between neurons via a prion-like mechanism, inducing the misfolding of normal -syn proteins, thereby accelerating degenerative changes in dopaminergic neurons (Liu et al., 2022)
So few documented side effects mainly reflects absence of rigorous data , not proof of safety
Tissue type considerations further support synergistic combinations
[Google Scholar] Sitohang I, Ninditya S