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[5] [7] At dosages exceeding 5 grams, there is a potential risk for more severe adverse effects, including renal dysfunction, blood toxicity, and neurological symptoms

Am J Hum Genet 81(2):252263

The developing nervous system appears to be especially vulnerable to vitamin E deficiency

As a result, Nrf2 escapes degradation and translocate to the nucleus, where it binds to Antioxidant Response Elements (AREs) within the promoter regions of target genes

Therefore, it improves its delivery to the bloodstream and cells