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Limitations of current evidence include small sample sizes, short study durations, heterogeneous patient populations, and varying dosing regimens

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They also have harmful effects on embryo development (Pietrzik and Bronstrup, 1997

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If that would not be enough, there is also a 2014 study showing that Pitera might be able to help with skin pigmentation and a 2015 study finding that Galactomyces Ferment Filtrate can activate aryl hydrocarbon receptor (AhR) that's important in epidermal homeostasis by upregulating epidermal barrier proteins

10.1155/2010/270832 215 ShimazuT.HirscheyM