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A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes

Study Results: 45% increase in delta wave sleep Reduced sleep onset latency Improved sleep efficiency scores Enhanced circadian rhythm stability Stress Response Research Findings Research published in Psychoneuroendocrinology demonstrated DSIPs effects on stress hormone regulation, showing significant reduction in cortisol response to stressors, normalized HPA axis function, improved stress adaptation markers, and enhanced resilience to chronic stress in experimental models

10.1002/jgh3.12410

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