Nonetheless, since mediation analyses rely on strong assumptions, these findings should be interpreted with caution, and causal inferences regarding the exact contribution of weight-independent pathways cannot be definitively established
Disclaimer: This blog post is for informational purposes only and should not be considered medical advice
Oxidative stress also activates the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 to regulate the expression of genes that control antioxidant, inflammatory and immune system responses, facilitating GSH activity
Endotoxins toxins released by certain bacteria can leak into the bloodstream when the gut barrier is damaged, triggering body-wide inflammation
Eligibility depends on stable weight, overall health, and medical evaluation
Reddy et al., 2021)