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Beyond glycemic control and weight loss, GLP-1-based therapies exhibit broader biological effects, including improvements in lipid metabolism, anti-inflammatory activity, reductions in oxidative stress, and favorable effects on vascular function and atherosclerosis, which contribute to cardiovascular risk reduction [2,3,4]
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Enhanced muscle fat oxidation and glucose transport by Acrp30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation
Recoverable but visible
This has implications not only for skin health but also for joint, nerve, and overall tissue regeneration
Preclinical studies have also pointed out that AMPK activates SIRT1 by up-regulating the NAD+ levels, which in turn promotes the deacetylation of SIRT1 and activates PGC-1, thereby forming the AMPK-SIRT1-PGC-1 signaling axis
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