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At higher doses, metformin confers protection via AMPK-independent inhibition of mitochondrial complex I (Mohsin et al., 2019)

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Neurology 48:113118 Lodi R, Iotti S, Cortelli P, Pierangeli G, Cevoli S, Clementi V, Soriani S, Montagna P, Barbiroli B (1997) Deficit of brain and skeletal muscle bioenergetics and low brain magnesium in juvenile migraine: an in vivo 31P magnetic resonance spectroscopy interictal study