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Paul Coates, former director of the Office of Dietary Supplements at the National Institutes of Health, reviewed many of the scientific studies on Protandim, including the one demonstrating a 7% increase in lifespan for male mice, and said he found them to be largely well designed, if small in scope

The MR-Egger method not only allows for testing and estimation of causal effects similar to the IVW method, but also facilitates evaluation of directional pleiotropy through the addition of a parameter, denoted as 0

Chang C-H, Tsai W-C, Hsu Y-H, Su Pang J-H

Those are different conversations

Drug Intell Clin Pharmacol 1986;20:1435