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doi: 10.1186/s40170-020-00229-2 104 Galan-CoboASitthideatphaiboonPQuXPoteeteAPisegnaMATongPet al

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While the mechanism is not yet proven, there is support for the idea that GLP-1 attenuates the ras homolog gene family, member A (RhoA)/Rho-associated protein kinase (ROCK) signaling pathway, whose activation is known to reduce levels of occludin, claudin-5, and zonula occludens-1 (ZO-1), as well as promote disruption of endothelial tight junctions

The bidirectional pathways between the gut and the brain, known as the gut-microbiome-brain axis, have long been recognized

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