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As of January 2025, Ozempic is now approved for use in patients with type 2 diabetes who also have chronic kidney disease

Therefore, the changes observed in the pain threshold test, OFT, and their reflection on brain electrical activity (EEG) are suggested to be a direct consequence of monoamine depletion and oxidative stress induced by reserpine 52

Weeks 1-4: 2.5mg weekly (subcutaneous, rotating injection sites) Weeks 5-8: 5mg weekly Weeks 9-12: 7.5mg weekly Week 13 onward: 10mg weekly (maintenance) Injection day: Every Sunday evening The injectable form was easier than I expected

Also, elevated GSH is not always correlated with enhanced tolerance to stresses such as metals (Xiang et al., 2001

Interestingly, physical function and QoL were not improved at the end of 8-weeks in any study arm

PMID 11089570