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Lipid profile improvements (TRIUMPH-4): Non-HDL cholesterol: Clinically meaningful reduction Triglycerides: Significant reduction hsCRP (inflammatory marker): Significant reduction HDL cholesterol: Not significantly improved (consistent with Phase 2 findings) The triglyceride reduction is particularly notable and likely related to glucagon receptor activation, which enhances fat oxidation

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Synthesis of (Fmoc-ABU) 2 -PEG 2k -PDHD Similarly, the protective group of Fmoc-Lys-PEG 2k -PDHD was removed

To avoid DMSO toxicity 11,12 , we designed water-soluble versions of CSD and its subregions (designated sCSD, sA, sB, sC, Table 1)

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