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Insulin Secretion Isolated islets were pre-incubated with baseline glucose concentration (5.6 mmol l 1 ) for 60 min in 1 ml of normal KrebsRinger solution [(mmol l 1 ): NaCl, 115

Gudzune KA, et al

Each experiment was performed in the fasted state (5 hours, beginning at start of dark cycle) in the same mice on different days

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It reduces appetite, slows gastric emptying, improves insulin sensitivity, and produces meaningful reductions in body weight over time