PMID 23858464
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Liraglutide also decreased angiotensin II-induced oxidative stress by increasing the levels of NADPH oxidase activity, increasing endothelial NO availability, and reducing immune cell infiltration by reducing the levels of F4/80 (a macrophage marker F4/80 with proinflammatory properties) expression in cardiac tissue thus reducing the overall level of oxidative stress in hypertensive heart disease
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Accordingly, approved indications expanded in early 2024 to include not only reduction of hyperglycemia, but also weight management in non-diabetic patients, and even cardiovascular risk reduction in patients with elevated weight and comorbid cardiovascular disease