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Seventy-two patients (age 1875 years) who received oral treatment with ALA (600 mg/day) for 40 days were enrolled in this study

Only the combined treatment with paracetamol and TRAIL lead to the processing of Bid into its active tBid form (p15) in both cell lines

Data are mean SEM, n = 8/group

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TMEM164 upregulation synergizes powerfully with anti-PD-1 therapy in vivo, demonstrating how engaging this axis can overcome immunotherapy resistance (13)