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Common approaches include 8 to 12 weeks on followed by 2 to 4 weeks off, or 4 weeks on with 2 weeks off repeated

According to FDA guidance, doses should be spaced at least 72 hours apart, and missed doses may be taken within 4 days (96 hours) of the scheduled time

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In particular, GSTP1-1 is able to protect the tumor cells from apoptosis signals by inhibiting c-Jun N-terminal kinase (JNK)a member of the MAPK pathwaynon-catalytically, by direct proteinprotein association 25,26