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The rare but serious side effects of GLP-1 therapy (pancreatitis, gallbladder disease, and thyroid concerns) appear to occur at similar rates with oral and injectable formulations

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It stimulates the pulsatile secretion of endogenous GH by the pituitary gland, which in turn activates downstream hepatic production of IGF-1

Landree LE, Hanlon AL, Strong DW, Rumbaugh G, Miller IM, Thupari JN, Connolly EC, Huganir RL, Richardson C, Witters LA, Kuhajda FP, Ronnett GV: C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism