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Zincs anti-inflammatory effects were also linked to inhibition of Notch1 pathway, which regulates M1 macrophage polarization [224]

In the control trial, rats were given saline at a dose of 5.0 ml/kg

In addition, aberrant Ca 2+ signaling causing mitochondrial dysfunction can adversely affect neurotransmitter signaling and lead to excitation/inhibition imbalance [94, 97, 98]

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