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Emerging evidence highlights a complex, bidirectional relationship between the gut microbiota and GLP-1 RAs, including semaglutide [82]

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The liver converts fatty acids from body fat into ketones like acetoacetate and beta-hydroxybutyrate

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The mechanistic consequence is that GHRP-6 activates the full biological program that ghrelin controls not just GH secretion, but somatostatin suppression, appetite signaling via NPY/AgRP pathways, gastric motility, and elements of the reward circuitry

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