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Description

Even in patients without genetic mutations, the Th2 inflammatory environment suppresses filaggrin expression epigenetically

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Additional pharmacological characterization by our group corroborates its hMC3R potency (EC 50 = 4.2 nM, E max = 91%) and demonstrates enhanced hMC4R potency (EC 50 = 0.048 nM, E max = 100%) (25)