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Safety and Regulatory Concerns Long-term use is restricted in many countries due to risks like skin thinning and rebound pigmentation

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It is important for its clinical use to point out that Lf is hydrolysed at the gastric level but this does not render it inactive or unable to perform its functions, in fact scientific evidence and several studies (including clinical ones) (Artym and Zimecki 2013

This was reported previously by Ibrahim et al (2021) and Singh and Kumar (2019)

SUSTAIN-4 vs insulin glargine)

[PubMed] [Google Scholar] 13.Lu S.C