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Given the high numbers of microbial cells and genes 18 , it is now evident that the gut microbiome can impact glucose and energy homeostasis via numerous mechanisms, including both impacting host gutbrain signaling and initiating direct communication to the brain via microbe-derived metabolites 19

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MT-IIs engagement with MC1R facilitates melanogenesis, while its binding to MC4R has shown significant potential in modulating sexual behaviors in females and erections in male study volunteers [13, 14]