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The GLP-1 receptor agonist (GLP-1RA) class has rapidly evolved from early injectable therapies for type 2 diabetes into one of the most important drug categories in metabolic disease treatment

Acknowledgements This work was supported in part by a Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science (23K06113) and World Premier International Research Center Initiative (WPI), MEXT, Japan

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Under conditions such as chronic inflammation or specific tissue microenvironments, NRF2 activation may promote ferroptosis by upregulating genes involved in iron metabolism and lipid peroxidation, particularly when antioxidant defenses are overwhelmed

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