Human cancer develops through diverse genetic, environmental and age-related pathways that cannot be represented by a single mouse model
The history of the pharmacotherapy of obesity dates back to the 1930s
The potential of zebrafish as drug discovery research tool in immune-mediated inflammatory disease
Glutathione is a key player in these pathways, but adding more doesn't strictly equate to better detoxification if your system isn't under specific stress
Takasu T, Takakura S (2019) Effect of ipragliflozin, an SGLT2 inhibitor, on cardiac histopathological changes in a non-diabetic rat model of cardiomyopathy
However, ICIs have shown limited efficacy in treating PDAC, predominantly because of the hostile TME characterized by fibrosis, hypoxia, and immunosuppression [148]