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Hydration also plays a significant role

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Neuropathy is believed to result from pyridoxine neurotoxicity to dorsal root ganglia when plasma levels are excessively high

Furthermore, many biomedical device companies have obtained patents on novel delivery devices using technology like smartphones or a voice signal to trigger the release of the drug in a controlled manner [41]

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When a compound has no completed human trial, there is by definition no safety data in any subgroup no pregnancy data, no hepatic-impairment data, no interaction data with common metabolic or endocrine medications