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They are administered by subcutaneous injection (weekly, daily, or twice-daily) or as an oral tablet (semaglutide), with pre-filled pens for self-administration

During caloric restriction, with or without GLP-1 aids, the weight lost by patients is a mix of lean mass and fat mass

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Notably, currently available therapies for RA, such as cytokine (TNF and IL-6) blockers or inhibitors of the JAK-STAT pathway 43 , exclusively tackle the inflammatory phase of the disease but do not interfere with the underlying processes that initiate the onset of arthritis and therefore often need to be given life-long 44

These targeted mechanisms can significantly reduce recovery time compared to traditional methods alone