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Constipation occurs in roughly 20% of patients because reduced food intake and slower digestion create less intestinal movement

Xu, X., Pang, Y

447 Moreover, these agents promote hemodynamic equilibrium, 18 diminish thrombotic propensity, 448 alleviate endothelial oxidative stress, 449 attenuate inflammatory processes, 450 and foster a favorable balance of the gut microbiota, 451 all of which collectively contribute to the salutary effects of these agents in patients with AS

When semaglutide binds to GLP-1 receptors in the pancreas, it helps increase insulin secretion based on glucose levels

Next, only 2 studies were eligible for inclusion in the indirect treatment comparison, which may limit the robustness of the comparison

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