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This is still a proposed model rather than a settled fact, so it is worth holding as the best current explanation and not the final word

Idris, I., Abdulla, H., Tilbrook, S., Dean, R

This complex metabolic disorder is accompanied by an increase in local and systemic inflammatory mediators, such as proinflammatory cytokines [e.g., interleukin (IL)-6 and IL-8 and tumor necrosis factor-alpha (TNF-)] [9, 10]

Dose response relationships are still under investigation, which means the safest and best option is to follow trial backed ranges and clinician advice rather than self escalate dramatically

1997;18:S137-S144

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