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By reframing neuroprotection as a systemic, multicellular endeavor, this review highlights the potential to not only extend life expectancy, but also preserve meaningful quality of life in individuals affected by neurodegenerative diseases

MSCs can release growth factors and anti-inflammatory cytokines, which aid in tissue repair and inflammation reduction in the lungs (87)

Intracellularly, pyridoxine is converted to its active form, pyridoxal phosphate (PLP), which is the only form of the vitamin capable of functioning as a cofactor for enzymes (, , , )

Additional oral supplementation with polypodium leucotomos extract (PLE) at 480 mg twice daily can be helpful (anecdotal evidence, unpublished)