Incretin triple agonist retatrutide (LY3437943) alleviates obesity-associated cancer progression
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Astrocytes are the exclusive possessors of glutamine synthetase in the brain, 137 which makes them the main target for ammonium
Focusing too much on weight can therefore be misleading
Unanswered Questions Regarding Weight Loss Mechanisms: Perspectives to Preclinical Research The exact mechanisms underlying the weight loss are still not clear, especially in light of the enhanced effects seen with multi-agonism, despite the large number of incretin agonists presently undergoing clinical trials and their remarkable effectiveness in managing obesity and T2DM [5, 14, 146, 147]
Li L, Shi L, Jia J, Eltayeb O, Lu W, Tang Y, et al