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There is no indication that long-term use changes this fundamental characteristic

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[DOI] [Google Scholar] 13.Pinto S., Correia-de-S T., Sampaio-Maia B., Vasconcelos C., Moreira P., Ferreira-Gomes J

Abstract Alcohol is generally believed to be metabolized in the liver by alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and to a much lesser extent cytochrome P450 2E1 (CYP2E1) and other enzymes