Further large-sample analyses and functional experiments may explain the aforementioned results
Individual results vary based on dose, adherence, diet , and exercise habits
It also activates VEGFR-2 (promoting angiogenesis), EGR-1 (a transcription factor for tissue repair genes), and the NO-system (nitric oxide signaling)
However, for melasma specifically, the strongest clinical evidence supports chemical peels, laser toning, topical depigmenting agents and oral tranexamic acid
These include: Procedures: Nerve blocks and trigger point injections to address nerve-related or muscle-based headache triggers
Moreover, its adverse effects can often be minimized by initiating the drug slowly