If you recently titrated up to a higher dose and your constipation dramatically worsened, that dose increase is likely the primary driver
Washington, DC, USA: American Chemical Society, 33-45
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This is why a targeted approach is so important
Although L-cells are classically described as endocrine cells, like enterochromaffin cells (Bellono et al., 2017), they can synapse directly with peripheral afferent and efferent neurons (Bohrquez et al., 2015), providing a direct neural pathway for bi-directional brain-gut communication (Kaelberer et al., 2018)
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