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Moreover, given that there are now millions of patient-years of clinical experience with DPP-4 inhibitors since they were given regulatory approval in 2006, their benign, placebo-like side effect profile (39) also suggests that the number of physiologically relevant substrates is likely to be limited

Notably, the PNA model mimics a lean phenotype with subtle metabolic alterations and may phenocopy the human phenotype B of PCOS 45 , characterized by hyperandrogenism and oligo-anovulation, with cycle irregularities

So basically the stress that acne gives you can actually make your skin take longer to get better

However, supplements don't seem to help

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Lets break down the science, set realistic timelines, and clear the confusion between expectation and realitywith honest insights from Dr