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Clinical trials consistently demonstrate that gastrointestinal symptoms are most pronounced during the initial weeks of treatment and typically diminish as the body adapts to the medication

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Figure 9 Discussion It is challenging to formulate effective treatment options for IBS since the symptom likely represents a variety of medical conditions ( Our systematic analysis of GLP-1 agonists impact on IBS-related pain and symptoms suggests a promising landscape for its use beyond standard metabolic applications

The opioids are believed to have some role in mediating GAL-induced feeding, since the opioid receptor agonist naloxone attenuates the GAL feeding response