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The co-primary outcomes of this study were changes in arterial stiffness and kidney oxygenation, with a specific focus on carotid-femoral pulse wave velocity as a measure of arterial stiffness

Most cycle changes reflect metabolic adaptation to caloric deficit rather than direct hormonal toxicity, making them potentially reversible once weight stabilizes or dosing adjusts

Both carry boxed warnings about thyroid tumors and potential risk of medullary thyroid carcinoma

Additionally, we provide important clinical evidence that 68 weeks of semaglutide 2.4 mg weekly may rival weight loss results from revisional metabolic surgery when undertaken for weight optimization after a suboptimal outcome to a primary surgical procedure, providing a minimally invasive and cost-effective alternative

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Carrying out a baseline scalp evaluation before starting Ozempic so that any hair loss can be identified