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Specifically, Mn overexposure has been shown to promote the exosomal transmission of -synuclein between neurons and microglia, triggering neuroinflammatory responses in vitro and in vivo (Harischandra et al., 2019

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Among those drugs, the combination of Dasatinib (D), a pan-inhibitor of tyrosine kinase receptors and Quercitin (Q), a flavonoid compound extract from plants targeting BCL-2 family members, is one of the most characterized as well as one of the most used in clinical trials to eliminate senescent cells