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The impact we are seeing in OA might be real, but we have to define it more clearly. Although no data are conclusive yet, preclinical studies have shown that GLP-1 receptor agonists can inhibit the NF-kB pathway, a key pathway involved in inflammation and cartilage destruction, according to Lane

It is established that gastroparesis is an unfortunate side effect of GLP-1 medications if taken for weight loss (Sodhi et al

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Nevertheless, I maintain vigilant monitoring of the thyroid in patients on these medications, particularly for those using them longer than 612 months

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CLM and TMA edited the manuscript, and read and approved the final version of the manuscript and agree with the order of presentation of the authors