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However, other experts, like researchers at the University of Southern California, think GLP-1s would have much greater cost savings, estimating theyd save up to $245 billion in the first 10 years if private insurers also covered the medications

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Other domains were also investigated in several of the included studies including the risk of meniscal repair failure (vertical, horizontal, radial, and root)

Limited contemporary human data

The real differentiator may be the metabolic preservation effects seen with CagriSema in preclinical models, but human data confirming this advantage is still limited

10.1016/j.cbpa.2021.01.015