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It targets three incretin and metabolic hormone receptors simultaneously the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor

The government is even getting in on the action with the recent launch of TrumpRx

This gut hormone has many important metabolic actions, including: The effectiveness and safety of Wegovy have been demonstrated in the Semaglutide Treatment Effect for People with Obesity (STEP) program

Studies of orforglipron (Foundayo) showed significant and sustained weight loss (at least 10% of starting weight) over 72 weeks

Proposed mechanisms include reduced inflammation, improved endothelial function, decreased blood pressure, improved lipid profiles, and direct cardioprotective effects via GLP-1 receptors expressed on cardiomyocytes

Maintain or increase exercise volume