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That 20% reduction in MACE is a landmark finding

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Adverse Event Reporting Report adverse reactions to the FDA MedWatch Program at 1-800-FDA-1088 or online at www.fda.gov/medwatch

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It promotes tissue fibrosis by binding to PDGF receptors, while excessive ECM deposition exacerbates vascular lesions and hypoxia, further aggravating fibrosis (162, 164, 165)