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Safety Considerations and Who Should Consult a Provider Retatrutide carries similar safety considerations to other GLP-1/GIP compounds: gastrointestinal side effects (nausea, vomiting, diarrhea), pancreatitis risk in susceptible individuals, and thyroid C-cell concerns noted in animal studies

Low blood sugar can happen more often when SYNJARDY or SYNJARDY XR is taken with certain other diabetes medicines

Without adequate protein, you risk losing muscle along with fat which undermines the metabolic benefits of your weight loss

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Because its designed with GLP-1 users in mind, it contains nutrients that may be difficult to get enough of with a significantly reduced appetite

Assessment of satiety depends on the energy density and portion size of the test meal: test meal affects satiety assessment