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Such regulation is crucial for maintaining the physiological pulsatility of GH , characterized by short bursts of hormone release that are essential for metabolic homeostasis and anabolic processes

No controlled trial has evaluated the combination

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They likely reflect the difference between pathological IGF-1 excess (which does appear to increase cancer risk and accelerate ageing in some models) and normalisation of IGF-1 in individuals whose levels have declined below an optimal physiological range due to somatopause

Epub 2023/11/30