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All participants provided verbal consent which was recorded on computers by trained interviewers

GIPR-bound tirzepatide is rotated by 8.3 compared to that in complex with GLP-1R, such a movement shifted its C terminus toward the TMD core by 5.2 (measured by the C of I27 P )

Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway

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In an in vivo study, the acute treatment with GLP-1 in female rats resulted in the increase of the amplitude of the preovulatory LH surge, likely by the activation of the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons [35]

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