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Studies show that people who lose weight on GLP-1 medications and then stop often regain 50-70% of that weight within the first year if lifestyle modifications aren't maintained

A subset of subjects ( n = 7 omnivores, n = 6 vegans/vegetarians) consented to provide feces at both baseline and the end of the study following at least 2 months of l-carnitine supplementation for analyses (Figure 5)

However, GLP-1 patients in Houston have experienced severe GI problems from drugs like Ozempic, even after they followed their doctor's orders to the letter

Katturajan R, Evan Prince S (2021) A role of connexin 43 on the drug-induced liver, kidney, and gastrointestinal tract toxicity with associated signaling pathways

Animal studies showed that exposure to GLP1-RAs was associated with small-for-gestational age pups (birthweight that is lower than expected at the time of delivery), and there was an increased risk of birth defects compared to unexposed animals

They generally improve as the body adjusts to the medication