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While surveying the literature in preparation of this manuscript we have also noticed and reported an increasing interest in the role that GSTs play in neurodegeneration, where isozymes belonging to the family may be either up-regulated, mutated or absent, according to the different diseases

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Certain medications use sublingual delivery specifically to bypass first-pass metabolism in the liver

However, our findings do not exclude the possibility that there are GSH alterations elsewhere in the autistic brain