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As the goal of early detection of patients at highest risk of poor outcome requires maximization of the sensitivity of the test score, it would seem reasonable to use the MDF (with a cutoff of 32, and/or the presence of encephalopathy) to select patients for therapy

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Retatrutide is synthetically engineered and produced using solid-phase peptide synthesis (SPPS)

It remains unclear why these differences were observed

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After 4 hours (Pfa1 xCT OE) or 24 hours (HeLa), cells were treated as indicated in the figure legends