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Certain studies demonstrated that a co-administration in ob/ob mice of GLP-1analogues, and GIP improved hypoglycemic, insulinotropic, and weight-reducing actions compared to the individual incretins [101,102,103,104,105,106,107]

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Although 11 studies (including nearly 6,000 patients) had a history of suicide attempt/depression as exclusion criteria for enrollment, removal of these studies did not affect the overall findings of the meta-analysis

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