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and refusal to provide written informed consent

Vitamin B 12 deficiency can develop for the following reasons: Absence of intrinsic factor, also called pernicious anemia: Intrinsic factor is a protein secreted by cells of the stomach lining

The tissue-specific distribution of beta-3 receptors (concentrated in fat tissue) further enhances selectivity

Deficiencies can occur with medical conditions such as atrophic gastritis (which causes thinning of the stomach lining), pernicious anaemia, Crohns disease, celiac disease, lupus, or other immune system disorders and certain medications

Rather, they are a necessary compliance measure for the distribution of research-use materials