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Vitamin D active ligand (1,25-dihydroxyvitamin D3 or calcitriol) normally binds to the VDR nuclear receptor, forming a heterodimer with the Retinoid X Receptor (RXR), which interacts with vitamin D response elements (VDREs) to regulate gene transcription ( It has been shown that high levels of vitamin D are associated with a lower risk of many cancer types ( A possible role of vitamin D supplementation in promoting cancer progression has also been reported, although the evidence is limited and primarily derived from observational associations

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